Department of Family & Community Medicine

Karen Tu MD,MSc
Professor
DFCM
Contact Info
Location
Central DFCM
500 University Avenue, 3rd floor
Toronto, ON, M5G 1V7
Accepting
Graduate Students
Postdoctoral Fellows
Research Interests
Health Informatics, Health Service Delivery, Electronic Medical Records, Administrative Databases, Quantitative Data Analysis, Chronic Diseases, Observational Studies

Dr. Karen Tu is a Professor in the Department of Family and Community Medicine at University of Toronto, with a cross appointment in the Institute of Health Policy, Management and Evaluation at the University of Toronto and a staff family physician at the University Health Network-Toronto Western Hospital Family Health Team. She received her MD from the University of Toronto and her MSc in Health Policy, Planning and Financing in a joint degree from the London School of Economics and the London School of Tropical Medicine. 

Research/Teaching

Research Synopsis

Dr. Karen Tu is the founder of the Electronic Medical Record Administrative data Linked Database (EMRALD) and has unique insights into the analysis electronic medical record (EMR) data. She has extensive experience and expertise in the use of primary care EMR data, administrative data and the validation of administrative data and EMR data algorithms for the identification of common chronic diseases. 

Grants

Liddy CE, Archibald DB, Bello A, Fairclough L, Horsley TA, Keely EJ, Kossey S, Kuziemsky CE, Lai L, Mitera G, Tuot D (PI’s), Affleck E, Afkham A, Asghari S, Audcent T, Becker M, Belanger CA, Benchimol EI, Braam B, Cook S, Deri A, Catherine A, Ens CD, Fraser-Roberts L, Hagens S, Hillmer M, Jaakkimainen LR, Kendall C, Klarenbach S, Kovacs CS, Macdonald SM, McRae S, Oppenheimer L, Poulin PA, Smyth CE, Tu K. Putting patients first: A national patient-centered evaluation of electronic consultations to improve access to specialists. CIHR Project Grant. 2016/04-2017/04. $100,000.

Sander BH, Evans GA, Patel S (PI’s), Deilgat MPP, Moore KM, Pullenayegum EM, Sider D, Swanson D, Tu K. Addressing the Health and Economic Burden of Lyme Disease. CIHR Project Grant. 2016/04-2017/04. $100,000.

Liu P (PI), Tu K, Tobe S, Kaczorowski J. Accelerated Canadian AppliCation of Evidence to Practice Through Monitoring of Outcomes Research team Endeavour (ACCEPT-MORE). Vascular Network 2016/6-2018/6. $300,000.

Shah BR (PI), Austin P, Ivers N, Katz A, O’Reilly D, Singer A, Tu K. Derivation of risk prediction models and a computer microsimulation model in type 2 diabetes to aid clinical decision making and health technology assessment. CIHR Project Grant. 2016/07 – 2019/06. $424,298. 

Tu K (PI), Frost D, Vembu S, Morris Q. Comparison of an Electronic Medical Record Text-based Tool to HARP for predicting emergency department visits and high system costs. BRIDGES. 2015/11-2016/3 $50,219.

Wilson S (PI), Crowcroft N,  Deeks S, Guttman A, Kwong J, Tu K. Use of Electronic Medical Record data to assess rotavirus vaccine coverage and predictors of vaccine uptake. Public Health Ontario. 2015/9 – 2016/8. $73,658. 

Tu K (PI), Bematsky S, Hawker G, Kreder H, Bombardier C, Butt D, Ivers N, Jaakimainen L, Jenkinson R, Kuriya B, Morris Q, Paterson M, Pope J, Ravi B, Thome C, Tomlinson G, Wasserstein D, Widdifield J. Leveraging EMRs and health administrative data to evaluate patient care and outcomes in rheumatic diseases. Canadian Institutes of Health Research. 2015/7 – 2016/6. $100,000.

Lee D (PI), Mak S, Farkouh ME, Tu JV (Co-PI’s), Austin PC, Ross HJ, Abrams H, Logan A, Ong S, Tu K, Pariser P, Petrella R, Husain A, Steinberg L, Straus S, Carm P, Sulway C, Wijeysundera H, Udell J, Laupacis A, Smith S, Tobe S, Liu P, Stewart D. Comparison of outcomes and access to care for heart failure (COACH) trial. Ontario SPOR Support Unit. 2015/6 – 2018/5. $1,750,000.

Ball G (PI), Birken C, Hamilton J, Holt N,  Masse L, Morrison K (co PI’s), Anderson L, Buchholz A, Carsley S, Chanoine JP, Cordeiro K, Dettmer E, Forhan M, Hadjiyannakis S, Haines, Ho J, Legault L, Luca P, Maguire J, Maximova K, McPherson A, Parkin P, Perez A, Sprague A, Tournay, Tremblay M, Tu K. Team to address bariatric care in Canadian children. Canadian Institutes of Health Research: Team Grant in Bariatric Care. 2014/12–2019/12. $1,480,801

Halperin S (PI), MacDonald S, Naus M, Crowcroft N, Deeks S, Kwong J, Tran D, Brisson M, Desai S, Drolet M, Peetsma L, Wilson S, Tu, K.  Canadian Immunization Research Network – Evaluation and gap analysis of federal and provincial/territorial systems and methodologies used to assess immunization coverage. Canadian Institutes of Health Research / Public Health Agency of Canada. 2014/6–2017/6. $2,200,000.

Tu K (PI), Tobe S, Ivers N, Jaakkimainen L, Butt D. Measuring performance in vascular disease management in primary care settings based on the Canadian Cardiovascular Harmonization of National Guidelines Endeavour. Vascular Network/ Canadian Institutes of Health Research and C-CHANGE eHealth. 2014/6–2016/6. $73,500.

Tu K (PI), Parkash R, Healey J, Nieuwlaat R, Ivers N, Atzema C. Validation of administrative data algorithms to identify patients with Atrial Fibrillation. Canadian Stroke Prevention Intervention Network (C-SPIN) / Canadian Institutes of Health Research. 2014/6–2015/6. $25,111.

Chen H (PI), Burnett RT, Kwong J, Tu K, Goldberg MS, Villeneuve PJ, Copes R. Development of neurodegenerative diseases from exposure to outdoor air pollution. Health Canada, Clean Air Research Agenda. 2014/04 – 2016/03. $200,000.

Tu K, (PI), Ivers N, Nash D, Jaakkimainen L. Chronic Kidney Disease EMRALD. Ontario Renal Network. 2013/11–2017/4. $737,638. [Contract]

Gershon A, Aaron S (Co-PIs), To T, Tu K, Bourbeau J, O’Donnell D, Licskai C. The Ontario Chronic Obstructive Pulmonary Disease (COPD) Population Health Network. Ontario Ministry of Health and Long-Term Care, Health System Research Fund Capacity Awards. 2014/7–2017/7 $1,048,564.

Kaczorowski J, Daly T, Dolovich L, Lussier M (Co-PI’s) Ahmad F, Angeles R, Chiu M, Dahrouge S, Fletcher A, Goeree R, Goudreau J, Jones C, Lalonde L, McDonough B, Nadeau-Grenier V, Paterson M, South J, Syed I, Tardif J, Thabane L, Tu K. Canadian Chronic disease Awareness and Management Program (C-CHAMP). Canadian Institutes of Health Research. 2013/4–2018/3. $2,496,974.

Jaakkimainen RL (PI), Barnsley J, Bronskill S, Butt DA, Del Giudice LM, Durbin J, Glazier RH, Ivers NM, Tu K, Upshur RE. Measuring wait times along the pathways of care in primary care. Canadian Institutes of Health Research. 2013/7–2016/6. $448,802.  

Tu K (PI), Dante M,  Bhatia S, Butt D, Meshkat N, Leblanc K, Thorpe K, Dorian P, Ivers N, Valentinis A, Saposnik G, Gladstone D, Jaakkimainen L. Improving stroke prevention for patients with Atrial Fibrillation in primary care. Heart and Stroke Foundation of Canada. Grant-in-Aid. 2013/7–2016/6. $211,261. 

Bombardier C, Tu K, Jaakkimainen L (Co-PIs), Ahluwalia V, Bernatsky S, Butt D, Hofstetter C, Ivers N, Lyddiatt A, Paterson M, Thorne C, Widdifield J. Optimizing the coordination of care between rheumatologists and primary care physicians for patients with inflammatory Arthritis. Canadian Initiative for Outcomes in Rheumatoid Arthritis (Canada). 2013/4–2015/4. $120,000.   

Tu K (PI), Barnsley J, Butt D, Glazier R, Hemmelgarn B, Ivers N, Jaakkimainen RL, Lau F, Thorpe K. Do EMRs in Primary care Improve quality of Care? (EPIC). Canadian Institutes of Health Research. Bridge Funding. 2013/4–2014/4. $100,000.   

Ray J (PI), Campbell D, Chiu M, Longo C, Maguire J, Sgro M, Tu K, Urquia M. Tailoring birthweight and infant growth curves to Canadians of various ethnic backgrounds. Canadian Institutes of Health Research. Healthcare Renewal Policy Analysis. 2013/3–2014/4. $134,800.   

Dahrouge S, Kaczorowski J (Co-PIs), Chambers L, Dolovich L, Paterson M, Thabane L, Tu K. Long-term effect of a community cardiovascular health awareness program: Five-year follow-up of community randomized trial. Canadian Institutes of Health. 2012/7–2013/7. $60,000.   

Jaakimainen L (PI), Tu K (Co-PI). EMR Wait Times Extension: Patient flow between Primary Care and specialist consultation. Canada Health Infoway. 2011/12 – 2012/1. $28,760. [Contract]

Tu J (PI), Alter D, Atzema C, Austin P, Bhatia S, Booth G, Garg A, Gershon A, Glazier R, Hillmer M, Hogg W, Kapral M, Ko D, Lee D, Lewis M, Manuel D, Palmer L, Stukel T, Tu K, Walton N, Wijeysundera H, You J. Measuring and improving the quality of ambulatory care for people with cardiovascular risk factors and/or chronic cardiovascular diseases.  Canadian Institutes of Health Research. 2011/11–2016/11. $2,000,000.

Bombardier C, Tu, K, Jaakkimainen RL (Co-PIs), Bernatsky S, Paterson M, Ahluwalia V, Ivers N, Thorne C, Tomlinson G. Creating an information system from a primary care Electronic Medical Record Administrative data Linked Database to improve Rheumatoid Arthritis surveillance and quality of care. Canadian Institutes of Health Research. 2011/11–2014/8. $337,240. 

Tu K (PI), Ivers N, Butt D, Jaakkimainen L, Kapral M, Lin E. Case definition validation study for mental illness and stroke surveillance in Canada. Public Health Agency of Canada. 2011/3–2012/6. $169,999. 

Tu K (PI), Jaakkimainen L, Zwarenstein M (Co-PIs), Ivers N, Tu J. Feedback Gap: A trial of goal-setting and action-plans to increase the effectiveness of audit and feedback interventions in primary care. Canadian Institutes of Health Research. 2011/3–2012/9. $151,194.

Tu K (PI), Jaakkimainen L, Butt D (co-PIs), Jette N, Guttman M, Herrmann N, O’Connor P, Ivers N, Tierney M, Lam R. Validation of administrative data algorithms to determine population prevalence and incidence of Alzheimer’s Disease, Dementia, Multiple Sclerosis, Epilepsy and Parkinson’s Disease. Public Health Agency of Canada. 2010/11–2013/8. $679,334.   

El Emam K, Tu K (Co-PI’s), Buckeridge D, Malin B, McDonald D, Mercer J, Sokolova M, Willison D. Privacy preserving methods for sharing longitudinal electronic health records. Canadian Institutes of Health Research. 2010/3–2013/2. $150,000.   

Jaakkimainen L(PI), Tu K, Barnsley J, Glazier R. Using an existing electronic medical record (EMR) to determine wait times from primary care. Canadian Institutes of Health Research. 2010/3–2011/3. $99,981.   

Shachak A (PI), Barnsley J, Jadad A, Lemieux-Charles L, Tu K. End-user support in the implementation of electronic health records in primary care: A case study of early adopters. Canadian Institutes of Health Research. 2009/4–2011/3. $170,289.   

Quan H, Hemmelgarn BR, Tu K, (Co-PI’s) Bartlett-Esquilant G, Campbell NRC, Hill MD, Khan NA, Lix LM, McAlister FA, Smith MJ, Svenson LW, Teare GF, Wielgosz AT. Assessment of Hypertension occurrence, management and outcomes in Canada. Canadian Institutes of Health Research. 2008/8–2012/7. $670,217.   

Chambers L, Dolovich L, Kaczorowski J (Co-PIs), Karwalajtys T, Gierman T, Sebaldt R, McDonough B, Farrell B, Thabane L, Tu K, Goeree R, Levitt C, Hogg W, Paterson M. Reinforcing CHAP+AP as a sustainable community-based stroke prevention program for Ontario. Ministry of Health Promotion. 2008/7–2010/3. $1,100,000.

Tu K (PI), Jaakkimainen L, Glazier RH, Greiver M. Development of an electronic medical record primary care research database. Ontario Ministry of Health and Long-Term Care. Primary Health Care Team and Family Health Teams Health System Accountability and Performance Division. 2008/4–2009/3. $266,061.   

Quan H (PI), Campbell N, Ghali W, Hemmelgarn B, Hill M, Khan N, McAlister F, Tu K. Validation of a coding algorithm to define Hypertension using administrative data. Canadian Institutes of Health Research. 2007/7–2009/1. $83,687.   

Tu J (PI), Alter D, Austin P, Mamdani M, Manuel D, Schull M, Ko D, Stukel T, Tu K, Lee D, Pilote L, et al. Canadian Cardiovascular Outcomes Research Team II – Access to quality cardiac care. Canadian Institutes of Health Research. 2006/4–2011/3. $4,214,550.   

Kaczorowski J (PI), Chambers L, Spence J, O’Donnell M, Karwalajtys, Hall H, Dolovich L, Farrell B, McDonough B, Sebaldt R, Levitt C, Hogg W, Thabane L, O’Rourke K, Goeree R, Tu K. Community Cardiovascular Health Awareness Program - Ontario Stroke Strategy (CHAP - OSS) Canadian Stroke Network. 2006/4–2008/3. $1,000,000.   

Kaczorowski J, Chambers L (Co-PIs), Spence J, O’Donnell M, Karwalajtys, Hall H, Dolovich L, Farrell B, McDonough B, Sebaldt R, Levitt C, Hogg W, Thabane L, O’Rourke K, Tu K, Goeree R. Cardiovascular Health Awareness Program – Ontario Stroke Strategy (CHAP – OSS). Ontario Ministry of Health and Long-Term Care. 2005/7–2006/6. $500,000.   

Jaakkimainen L (PI), Upshur R, Barnsley J, Berta W, Bondy S, Chan B, Del Guidice L, Gillis L, Glazier R, Guttman A, Manuel D, Rhodes A, Stukel T, Tu K. Primary health care in Ontario: A practice atlas. Primary Health Care Transition Fund. 2004/8–2006/7. $749,454.   

Tu K (PI), McAlister FA, Campbell NRC, Hux JE. Developing methodology for examining trends in the management of Hypertension. Heart and Stroke Foundation of Ontario. 2004/7–2006/6. $127,006.   

Tu K (PI), Hux JE, Mamdani MM, Jaakkimainen L, Manuel DG, Tu JV. Evaluation project of primary healthcare payment and delivery models on the screening, detection and control of Hypertension.  Primary Health Care Transition Fund. 2004/3–2006/2. $535,500.   

Tu K (PI), Mamdani MM, Tu JV. Treatment of Hypertension in Ontario: Have Hypertension guidelines had an impact? Ontario Program for Optimal Therapeutics. 1999/11–2001/10. $85,800.    

Publications and Awards

Recent Publications

Jaakkimainen RL, Bronskill SE, Tierney MC, Herrmann N, Green D, Young J, Ivers N, Butt D, Tu K. Identification of physician-diagnosed Alzheimer’s disease and related dementias in population-based administrative data: a validation study using family physicians’ electronic medical records. Journal of Alzheimer’s Disease. 2016 Aug; 54(1): 337-49.

Tu K, Nieuwlaat R, Cheng S, Wing L, Ivers N, Atzema CL, Healey JS, Dorian P. Identifying Patients with Atrial Fibrillation using Administrative Data. Canadian Journal of Cardiology. 2016 June doi: 10.1016/j.cjca.2016.06.006

Widdifield J, Tu K, Thorne JC, Bombardier C, Paterson JM, Jaakkimainen L, Wing L, Butt DA, Ivers N, Hofstetter C, Lyddiatt A, Ahluwalia V, Bernatsky S. Patterns of care among first-time referrals to rheumatologists: Characteristics and timeliness of consultations and treatment in Ontario, Canada. Arthritis Care and Research. 2016 Apr; doi: 10.1002/acr.22910

Widdifield J, Bernatsky S, Thorne JC, Bombardier C, Jaakkimainen RL, Wing L, Paterson JM, Ivers N, Butt D, Lyddiatt A, Hofstetter C, Ahluwalia V, Tu K. Wait times to rheumatology care for patients with rheumatic diseases: a data linkage study of primary care electronic medical records and administrative data. Canadian Medical Association Journal Open. 2016 May; 4(2):E2015-12.

Breiner A, Widdifield J, Katzberg H, Barnett C, Vera B, Tu K. Epidemiology of myasthenia gravis in Ontario, Canada. Neuromuscular Disorders. 2015 Oct; 26:41-46.

Schwartz KL, Tu K, Wing L, Campitelli MA, Crowcroft NS, Deeks SL, Wilson SE, Wilson K, Gemmill I, Kwong J. Validation of infant immunization billing codes in administrative data. Human Vaccines & Immunotherapeutics. 2015 Sept; 11(7): 1840-7. 

Tu K, Widdifield J, Young J, Oud W, Ivers N, Butt D, Leaver C, Jaakkimainen L. Are family physicians comprehensively using electronic medical records such that the data can be used for secondary purposes? A Canadian perspective. BMC Medical Informatics and Decision Making. 2015 Aug; 15:67.

Myers M, Kaczorowski J, Paterson JM, Dolovich L, Tu K. Thresholds for diagnosing Hypertension based upon automated office blood pressure measurements and cardiovascular risk. Hypertension. 2015 Aug; 66:489-495

Widdifield J, Ivers N, Young J, Green D, Jaakkimainen L, Butt D, O’Connor P, Tu K. Development and validation of an administrative data algorithm to estimate the disease burden and epidemiology of Multiple Sclerosis in Ontario, Canada. Multiple Sclerosis Journal. 2015 Jul; 21(8):1045-1054.

Peng M, Chen G, Lix LM, McAlister FA, Tu K, Campbell N, Hemmelgarn GR, Svenson LW, Quan H. Refining Hypertension surveillance to account for potentially misclassified cases. PLoS One. 2015 March; 10(3):e0119186.

Breiner A, Young J, Green D, Katzberg H, Barnett C, Bril V, Tu K. Canadian administrative health data can identify patients with Myasthenia Gravis. Neuroepidemiology. 2015 March; 44(2):108-113. 

Tu J, Chu A, Donovan L, Ko D, Booth G, Tu K, Maclagan L, Guo H, Austin P, Hogg W, Kapral M, Wijeysundera H, Atzema C, Gershon A, Alter D, Lee D, Jackevicius C, Bhatia R, Udell J, Rezai M, Stukel T. The Cardiovascular Health in Ambulatory Care Research Team (CANHEART): Using big data to measure and improve cardiovascular health and health care services. Circulation: Cardiovascular Quality and Outcomes. 2015 March; 8(2):204-212. 

Krysko, KM, Ivers NM, Young J, O’Connor P, Tu K. Identifying individuals with Multiple Sclerosis in an electronic medical record. Multiple Sclerosis Journal. 2015 Feb; 21(2):217-224.

Allin S, Munce S, Jaglal S, Butt D, Young J, Tu K. Capture of Osteoporosis and fracture information in an Electronic Medical Record Database from primary care. AMIA Annu Symp Proc. 2014 Nov; 2014:240. 

Butt D, Tu K, Young J, Green D, Wang M, Ivers N, Jaakkimainen L, lam R, Guttman M. A validation study of administrative data algorithms to identify patients with Parkinsonism with prevalence and incidence trends. Neuroepidemiology. 2014 Oct; 43(1):28-37. 

Tu K, Anderson LN, Butt DA., Quan H, Hemmelgarn BR, Campbell NR, McAlister FA. Antihypertensive drug prescribing and persistence among new elderly users: Implications for persistence improvement interventions. Can J Cardiol. 2014 Jun; 30(6):647-52. 

Clement F, Chen G, Khan N, Tu K, Campbell N, Smith M, Quan H, Hemmelgarn B, McAlister F. Primary care physician visits by patients with incident Hypertension. Can J Cardiol. 2014 Jun; 30(6):653-60. 
    
Widdifield J, Bombardier C, Bernatsky S, Paterson JM, Green D, Young J, Wang M, Ivers N, Butt D, Jaakkimainen L, Thorne JC, Tomlinson G, Ahluwalia V, Tu K. An administrative data validation study of the accuracy of algorithms for identifying Rheumatoid Arthritis: The influence of the reference standard on algorithm performance. BMC Musculoskeletal Disorders. 2014 Jun; 15:216. 

Butt D, Mamdani M, Gomes T, Lix L, Lu H, Tu K. Risk of osteoporotic fractures with Angiotensin II receptor blockers versus Angiotensin Converting-Enzyme inhibitors in hypertensive community-dwelling elderly. Journal of Bone and Mineral Research. 2014 May; 29(11):2483-8. 

Blais C, Dai S, Waters C, Robitaille C, Smith M, Svenson LW, Reimer K, Casey J, Puchtinger R, Johansen H, Gurevich Y, Lix LM, Quan H, Tu K. Assessing the burden of hospitalized and community-care heart failure in Canada. Can J Cardiol. 2014 Mar; 30(3):352-8. 

Tu K, Wang M, Jaakkimainen RL, Butt D, Ivers NM, Young J, Green D, Jette N. Assessing the validity of using administrative data to identify patients with Epilepsy. Epilepsia. 2014 Feb; 55(2):335-43. 

Grad RM, Pluye P, Shulha M, Tang DL, Tu K, Goodman K, Meuser J. EBM, CME and the EMR. Evid Based Med. 2014 Feb; 19(1):1-3.

Tu K, Mitiku TF, Ivers NM, Guo H, Lu H, Jaakkimainen L, Kavanagh DG, Lee DS, Tu JV. Evaluation of Electronic Medical Record Administrative data Linked Database (EMRALD). Am J Manag Care. 2014 Jan; 20(1):e15-e21.

Jaakkimainen RL, Glazier RH, Barnsley J, Salkald  E, Lu H, Tu K. Waiting to see the specialist. Patient and provider characteristics of wait times from primary to specialty care. BMC Family Pract. 2014 Jan;15:16. 

Ivers NM, Tu K, Young J,  Francis JJ,  Barnsley J, Shah BR, Upshur REG, Moineddin R, Grimshaw JM, Zwarenstein M. Feedback GAP: Pragmatic, cluster-randomized trial of goal setting and action plans to increase the effectiveness of audit and feedback interventions in primary care. Implementation Sci. 2013 Dec; 8:142. 

Tu K, Wang M, Young J, Green D, Ivers NM, Butt D, Jaakkimainen L, Kapral M. Validity of administrative data for identifying patients who have had a stroke or TIA using the primary care Electronic Medical Record Administrative data Linked Database (EMRALD) as a reference standard. Can J Cardiol. 2013 Nov; 29(11):1388-94.

Widdifield J, Paterson JM, Bernatsky S, Tu K, Thorne JC, Ahluwalia V, Ivers N, Butt D, Jaakkimainen RL, Tomlinson G, Bombardier C. The rising burden of Rheumatoid Arthritis surpasses rheumatology supply in Ontario. Canadian Journal of Public Health. 2013 Oct; 104(7):e450-5. 

Robitaille C, Bancej C, Dai S, Tu K, Rasali D, Blais C, Plante C, Smith M, Svenson LW, Reimer K, Casey J, Puchtinger R, Johansen H, Gurevich Y, Waters C, Lix LM, Quan H. Surveillance of Ischemic Heart Disease should include physician billing claims: Population-based evidence from administrative health data across seven Canadian provinces. BMC Cardiovas Disord. 2013 Oct; 13(1):88. 

Butt DA, Mamdani M, Austin PC, Tu K, Gomes T, Glazier RH. The risk of falls on initiation of antihypertensive drugs in the elderly. Osteoporosis Int. 2013 Oct; 24(10):2649-57. 

Jaakkimainen RL, Schultz SE, Tu K. Effects of implementing electronic medical records on primary care billings and payments: A before-after study. CMAJ Open. 2013 Oct; 1(3):e120-126. 

Schultz S, Chen Z, Rothwell D, Tu K. Identifying cases of Congestive Heart Failure from administrative data: A validation study using primary care patient records. Chronic Dis Inj Can. 2013 Jun; 33(3):160-166. 

Quan H, Chen C, Tu K, Bartlett G, Butt DA, Campbell NRC, Hemmelgarn BR, Hill MD, Johansen H, Khan N, Lix LM, Smith M, Svenson L, Walker RL, Wielgosz A, McAlister FA for Hypertension Outcome and Surveillance Team. Outcomes among 3.5 million newly diagnosed hypertensive Canadians. Can J Cardiol. 2013 May; 29(5):592-7. 

Butt DA, Mamdani M, Austin PC, Tu K, Gomes T, Glazier RH. The risk of hip fracture after initiating antihypertensive drugs in the elderly. Arch Intern Med. 2012 Dec; 172(22):1739-44. 

Quan H, Smith M, Bartlett-Esquilant G, Johansen H, Tu K, Lix L. Mining administrative health databases to advance medical science: Geographical considerations and untapped potential in Canada. Can J Cardiol. 2012 Mar; 28(2):152-4.

Robitaille C, Dai S, Waters C, Loukine L, Bancej C, Quach S, Ellison J, Campbell N, Tu K, Reimer K, Walker R, Smith M, Blais C, Quan H. Diagnosed Hypertension in Canada: Incidence, prevalence and associated mortality. CMAJ. 2012 Jan; 184(1): e49-56. 

Walker RL, Chen G, Campbell NR, McAlister FA, Quan H, Tu K, Khan NA, Hemmelgarn BR. Canadian Hypertension Education Program Outcomes Research Task Force. Canadian provincial trends in antihypertensive drug prescriptions between 1996 and 2006. Can J Cardiol. 2011 Jul; 27(4):461-7. 

Shachak A, Barnsley J, Tu K, Jadad AR, Lemieux-Charles L. Understanding end-user support for health information technology: A theoretical framework. Inform Prim Care. 2011 Jun; 19(3):169-72. 

Tu K, Manuel D, Lam K, Kavanagh D, Mitiku TF, Guo H. Diabetics can be identified in an electronic medical record using laboratory tests and prescriptions. J Clin Epidemiol. 2011 Apr; 64(4):431-5. 

Kaczorowski J, Chambers LW, Dolovich L, Paterson JM, Karwalajtys T, Gierman T, Farrell B, McDonough B, Thabane L, Tu K, Zagorski B, Goeree R, Levitt CA, Hogg W, Laryea S, Carter MA, Cross D, Sabaldt RJ. Improving cardiovascular health at population level: 39 community cluster randomised trial of Cardiovascular Health Awareness Program (CHAP). BMJ. 2011 Feb; 342:d442. 

Ivers NM, Pylypenko B, Tu K. Identifying patients with Ischemic Heart Disease in an Electronic Medical Record. Journal of Primary Care and Community Health. 2011 Jan; 2(1):49-53. 

Ivers NM, Tu K, Francis J, Barnsley J, Shah B, Upshur R, Kiss A, Grimshaw JM, Zwarenstein M. Feedback GAP: Study protocol for a cluster-randomized trial of goal setting and action plans to increase the effectiveness of audit and feedback interventions in primary care. Implementation Sci. 2010 Dec; 17(5):98. 

Shah ND, Montori VM, Krumholz HM, Tu K, Alexander GC, Jackevicius CA. Responding to an FDA warning – Geographic variation in the use of Rosiglitazone. N Engl J Med. 2010 Nov; 363(22):2081-4. 

Tu K, Mitiku T, Guo H, Lee DS, Tu JV. Myocardial Infarction and the validation of physician billing and hospitalization data using electronic medical records. Chronic Dis Can. 2010 Sep; 30(4):141-6. 

Tu K, Mitiku T, Lee DS, Guo H, Tu JV. Validation of physician billing and hospitalization data to identify patients with ischemic heart disease using data from the Electronic Medical Record Administrative data Linked Database (EMRALD). Can J Cardiol. 2010 Jul; 26(7):e225-8. 

Tu K, Klein-Geltink J, Mitiku TF, Mihai C, Martin J. De-identification of primary care electronic medical records free-text data in Ontario, Canada. BMC Med Inform Decis Mak. 2010 Jun; 18(10):35. 

Klarenbach SW, McAlister FA, Johansen H, Tu K, Hazel M, Walker R, Zarnke KB, Campbell NR. Identification of factors driving differences in cost effectiveness of first-line pharmacological therapy for uncomplicated Hypertension. Can J Cardiol. 2010 May; 26(5):e158-63.

Friedman O, McAlister FA, Yun L, Campbell NR, Tu K, Canadian Hypertension Education Program Outcomes Research Taskforce. Antihypertensive drug persistence and compliance among newly treated elderly hypertensives in Ontario. Am J Med. 2010 Feb; 123(2):173-81. 

Lee D, Chiu M, Manuel D, Tu K, Wang X, Austin P, Mattern M, Mitiku T, Svenson L, Putnam W, Flanagan W, Tu J for the Canadian Cardiovascular Outcomes Research Team. Trends in risk factors for cardiovascular disease in Canada: Temporal, socio-demographic and geographic factors. CMAJ. 2009 August; 181(3-4):e55-66. 

Tu K. Hypertension management by family physicians: Is it time to pat ourselves on the back? 2009 Jul; 55(7):686-7. 

Tu K, Cauch-Dudek K, Chen Z. Comparison of primary care physician payment models in the management of Hypertension. Can Fam Physician. 2009 Jul; 55(7):719-27. 

Mitiku TF, Tu K. Using Data from Electronic Medical Records: Theory vs Practice. An ICES Report. Healthcare Quarterly. 2008 Sept; 11(4):23-5. 

Kaczorowski J, Chambers LW, Karwalajtys T, Dolovich L, Farrell B, McDonough B, Sebaldt R, Levitt C, Hogg W, Thabane L, Tu K, Goeree R, Paterson JM, Shubair M, Gierman T, Sullivan S, Carter M. Cardiovascular Health Awareness Program (CHAP): A community cluster-randomised trial among elderly Canadians. Prev Med. 2008 Jun; 46(6):537-44. 

Hemmelgarn BR, Chen G, Walker R, McAlister FA, Quan H, Tu K, Khan N, Campbell N. Trends in antihypertensive drug prescriptions and physician visits in Canada between 1996 and 2006. Can J Cardiol. 2008 Jun; 24(6):507-12. 

Tu K, Chen Z, Lipscombe LL, Canadian Hypertension Education Program Outcomes Research Taskforce. Mortality among patients with hypertension from 1995 to 2005: A population-based study. CMAJ. 2008 May; 178(11):1436-40. 

Tu K, Chen Z, Lipscombe LL, Canadian Hypertension Education Program Outcomes Research Taskforce. Prevalence and incidence of hypertension from 1995 to 2005: A population-based study. CMAJ. 2008 May; 178(11):1429-35.

Zwarenstein M, Hux JE, Kelsall D, Paterson M, Grimshaw J, Davis D, Laupacis A, Evans M, Austin PC, Slaughter PM, Shiller SK, Croxford R, Tu K. The Ontario printed educational message (OPEM) trial to narrow the evidence-practice gap with respect to prescribing practices of general and family physicians: a cluster randomized controlled trial, targeting the care of individuals with Diabetes and Hypertension in Ontario, Canada. Implementation Sci. 2007 Nov; 2:37.

Campbell NR, McAlister FA, Duong-Hua M, Tu K. Polytherapy with two or more antihypertensive drugs to lower blood pressure in elderly Ontarians. Room for improvement. Can J Cardiol. 2007 Aug; 23(10):783-7. 

McAlister FA, Tu K, Majumdar SR, Padwal R, Chen Z, Campbell NR. Laboratory testing in newly treated elderly hypertensive patients without co-morbidities: A population-based cohort study. Open Med. 2007 Jun; 1(2):e60-7. 

Joffres MR, Campbell NR, Manns B, Tu K. Estimate of the benefits of a population-based reduction in dietary sodium additives on Hypertension and its related health care costs in Canada. Can J Cardiol. 2007 May; 23(6):437-43. 

Tu K, Campbell NR, Chen Z, McAlister FA. Use of beta-blockers for uncomplicated Hypertension in the elderly: A cause for concern. J Hum Hypertens. 2007 Apr; 21(4):271-5. 

Tu K, Campbell NR, Chen ZL, Cauch-Dudek KJ, McAlister FA. Accuracy of administrative databases in identifying patients with Hypertension. Open Med. 2007 Apr; 1(1):e18-26. 

Merkens BJ, Mowbray RD, Creeden L, Engels PT, Rothwell DM, Chan BT, Tu K. A rural CT scanner: Evaluating the effect on local health care. Can Assoc Radiol J. 2006 Oct; 57(4):224-31. 

Tu K, Gunraj N, Mamdani M. Is Ramipril really better than other Angiotensin-Converting Enzyme inhibitors after acute Myocardial Infarction? Am J Cardiol. 2006 Jul; 98(1):6-9. 

Tu K, Campbell NR, Chen Z, McAlister FA. Thiazide diuretics for Hypertension: Prescribing practices and predictors of use in 194,761 elderly patients with Hypertension. Am J Geriatr Pharmacother. 2006 Jun; 4(2):161-7. 

McAlister FA, Campbell NR, Duong-Hua M, Chen Z, Tu K. Antihypertensive medication prescribing in 27,822 elderly Canadians with Diabetes over the past decade. Diabetes Care. 2006 Apr; 29(4):836-41. 

Campbell NR, Tu K, Brant R, Duong-Hua M, McAlister FA. Canadian Hypertension Education Program Outcomes Research Task Force. The impact of the Canadian Hypertension Education Program on antihypertensive prescribing trends. Hypertension. 2006 Jan; 47(1):22-8. 

Simpson N, Anderson R, Sassi F, Pitman A, Lewis P, Tu K, Lannin H. The cost-effectiveness of neonatal screening for Cystic Fibrosis: An analysis of alternative scenarios using a decision model. Cost Effectiveness and Resource Allocation. 2005 Aug; 3(6):8-19.

Tu K, Campbell NR, Duong-Hua M, McAlister FA. Hypertension management in the elderly has improved: Ontario prescribing trends, 1994 to 2002. Hypertension. 2005 Jun; 45(6):1113-8.

Tu K, Mamdani M, Kopp A, Lee D. Comparison of Angiotensin-Converting Enzyme inhibitors in the treatment of Congestive Heart Failure. American J Cardiol. 2005 Jan; 95(2):283-86.

Tu K, Gong Y, Austin PC, Jaakimanian L, Tu JV. Canadian Cardiovascular Outcomes Research Team. An overview of the types of physicians treating acute cardiac conditions in Canada. Can J Cardiol. 2004 Mar; 20(3):282-91. 

Austin PC, Mamdani MM, Tu K, Zwarenstein M. Changes in prescribing patterns following publication of the ALLHAT trial. JAMA. 2004 Jan; 291(1):44-5. 

Jackevicius CA, Tu K, Filate WA, Brien SE, Tu JV, Canadian Cardiovascular Outcomes Research Team. Trends in cardiovascular drug utilization and drug expenditures in Canada between 1996 and 2001. Can J Cardiol. 2003 Nov; 19(12):1359-66. 

Cheng RM, Mamdani M, Jackevicius CA, Tu K. Association between ACE inhibitors and acute pancreatitis in the elderly. Ann Pharmacother. 2003 Jul; 37(7-80):994-8. 

Austin PC, Mamdani MM, Tu K, Jaakkimainen L. Prescriptions for estrogen replacement therapy in Ontario before and after publication of the Women's Health Initiative Study. JAMA. 2003 Jun; 289(24):3241-2. 

Tu K, Mamdani MM, Jacka RM, Forde NJ, Rothwell DM, Tu JV. The striking effect of the Heart Outcomes Prevention Evaluation (HOPE) on Ramipril prescribing in Ontario. CMAJ. 2003 Mar; 168(5):553-7. 

Lau E, Mamdani M, Tu K. Inhaled or systemic corticosteroids and the risk of hospitalization for hip fracture among elderly women. Am J Med. 2003 Feb; 114(2):142-5. 

Tu K, Mamdani MM, Tu JV. Hypertension guidelines in elderly patients: Is anybody listening? Am J Med. 2002 Jul; 113(1):52-8. 

Tu K, Davis D. Can we alter physician behavior by educational methods? Lessons learned from studies of the management and follow-up of hypertension. J Contin Educ Health Prof.  2002 Winter; 22(1):11-22. 

Tu K, Mamdani MM, Hux JE, Tu JB. Progressive trends in the prevalence of Benzodiazepine prescribing in older people in Ontario, Canada. J Am Geriatr Soc. 2001 Oct; 49(10):1341-5. 

Mamdani MM, Tu K, van Walraven C, Austin PC, Naylor CD. Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy. CMAJ. 2000 May; 162(10):1421-4. 

Honours and Awards

Ten Most Notable Family Medicine Research Studies in Canada by Canadian Family Physician. 07/2015. For Improving cardiovascular cluster randomized trial of Cardiovascular Health Awareness Program (CHAP) study.

Twenty Top Papers to Mark The BMJ’s Two Digital Decades. 07/2015. For J Kaczorowski, L W Chambers, L Dolovich et al. Improving Cardiovascular Health at Population Level: 39 Community Cluster Randomised Trial of Cardiovascular Health Awareness Program (CHAP). Research BMJ. 2011; 342:d442.

Research Excellence (Senior) Award University of Toronto, DFCM Awards of Excellence, 2014/5. Tu K.

CIHR–CMAJ Top Canadian Achievements in Health Research Awards. 2012/9. For Kaczorowski J, Chambers LW, Dolovich L, Paterson JM, Karwalajtys T, Gierman T, Farrell B, McDonough B, Thabane L, Tu K, Zagorski B, Goeree R, Levitt CA, Hogg W, Laryea S, Carter MA, Cross D, Sabaldt RJ. Improving cardiovascular health at population level. BMJ. 2011 Feb; 342:d442. 

American Heart Association, Council on Epidemiology and Prevention, Top Advances in Epidemiology and Prevention for 2011. 2012/9. For Kaczorowski J, Chambers LW, Dolovich L, Paterson JM, Karwalajtys T, Gierman T, Farrell B, McDonough B, Thabane L, Tu K, Zagorski B, Goeree R, Levitt CA, Hogg W, Laryea S, Carter MA, Cross D, Sabaldt RJ. Improving cardiovascular health at population level. BMJ. 2011 Feb; 342:d442. 

Outstanding Family Medicine Research Article College of Family Physicians of Canada.  2012/8 For Kaczorowski J, Chambers LW, Dolovich L, Paterson JM, Karwalajtys T, Gierman T, Farrell B, McDonough B, Thabane L, Tu K, Zagorski B, Goeree R, Levitt CA, Hogg W, Laryea S, Carter MA, Cross D, Sabaldt RJ. Improving cardiovascular health at population level. BMJ. 2011 Feb; 342:d442. Society for Clinical Trials.  

Finalist in the Research Paper of the Year category at the British Medical Journal (BMJ) Group Improving Health Awards. 2012/5. For Kaczorowski J, Chambers LW, Dolovich L, Paterson JM, Karwalajtys T, Gierman T, Farrell B, McDonough B, Thabane L, Tu K, Zagorski B, Goeree R, Levitt CA, Hogg W, Laryea S, Carter MA, Cross D, Sabaldt RJ. Improving cardiovascular health at population level. BMJ. 2011 Feb; 342:d442. 

CIHR Fellowship Award in the Area of Primary Care Canadian Institutes of Health Research. $100,000. 2011/3–2013/3

Certificate of Excellence Award from Blood Pressure Canada. 2011/9. For Kaczorowski J, Chambers LW, Dolovich L, Paterson JM, Karwalajtys T, Gierman T, Farrell B, McDonough B, Thabane L, Tu K, Zagorski B, Goeree R, Levitt CA, Hogg W, Laryea S, Carter MA, Cross D, Sabaldt RJ. Improving cardiovascular health at population level. BMJ. 2011 Feb; 342:d442. 

Distinguished Paper. North American Primary Care Research Group. 2010/11. For Kaczorowski J, Chambers LW, Dolovich L, Paterson JM, Karwalajtys T, Gierman T, Farrell B, McDonough B, Thabane L, Tu K, Zagorski B, Goeree R, Levitt CA, Hogg W, Laryea S, Carter MA, Cross D, Sabaldt RJ. Improving cardiovascular health at population level. BMJ. 2011 Feb; 342:d442.

Top Breakthroughs, Co-Chairs Award for Impact 1st Canadian Stroke Congress. 2010/6. For Kaczorowski J, Chambers LW, Dolovich L, Farrell B, McDonough B, Sebaldt R, Thabane L, Tu K, Zagorski B, Goeree R, Paterson JM, Karwalajtys T. Improving cardiovascular health at the population level: A 39 community cluster-randomised trial of the Cardiovascular Health Awareness Program (CHAP). 

Best Original Research Article Award 2010 Canadian Family Physician (CFP). 2010/1–2010/12. Tu K, Cauch-Dudek K, Chen Z. Comparison of primary care physician payment models in the management of hypertension. Can Fam Physician. 2009 Jul; 55(7):719–27.

Department of Family and Community Medicine Outstanding Research Publication. 2009. University of Toronto.  2009/1-2009/12. Tu K, Cauch-Dudek K, Chen Z. Comparison of primary care physician payment models in the management of hypertension. Can Fam Physician. 2009 Jul; 55(7):719–27.

Robert E. Beamish Award for significant contribution to the field of cardiology, as demonstrated by the impact of original research published in The Canadian Journal of Cardiology Canadian Cardiovascular Society. 2008/10. For Joffres MR, Campbell NR, Manns B, Tu K. Estimate of the benefits of a population-based reduction in dietary sodium additives on hypertension and its related health care costs in Canada. Can J Cardiol. 2007; 23(6):437–43.

Short-Term Clinician Investigator Award Canadian Institutes of Health Research. $25,000. 2005/3–2005/5

Robert E. Beamish Award for significant contribution to the field of cardiology, as demonstrated by the impact of original research published in The Canadian Journal of Cardiology Canadian Cardiovascular Society. 2005/10. For The CCORT Canadian Cardiovascular Atlas. 

Department of Family and Community Medicine Outstanding Research Publication. 2002. University of Toronto. 2002/1–2002/12.  For Tu K, Mamdani MM, Tu JV. Hypertension guidelines in elderly patients: Is anybody listening? Am J Med. 2002 Jul; 113(1):52–8.